Anastasia Yendiki

I am an associate professor at Harvard Medical School and an associate investigator at Massachusetts General Hospital. My research focuses on computational methods for mapping the white-matter axon bundles through which the different regions of the human brain communicate with each other. Our goal is to do this non-invasively, to allow clinicians and researchers to study these connections in living human subjects. For this purpose, we develop algorithms for analyzing diffusion-weighted MRI brain scans. However, the resolution of these quick scans is not sufficient for reconstructing the full complexity of the wiring of the human brain, leaving room for errors and ambiguities. We try to resolve these by using multi-modal data with microscopic resolution that are only available post mortem. This includes ex vivo diffusion-weighted MRI data that we collect in specialized research MRI scanners, as well as optical imaging and anatomic tracing data collected by our collaborators. Our ultimate goal is to develop models of white-matter anatomy from these post mortem data that will allow us to resolve the ambiguities in the lower-resolution in vivo data, with the hope of providing a reliable tool for the study of brain connections in patients with neurologic and psychiatric conditions, based on a quick and safe MRI scan.

See also:

Mapping the human brain: Advancing treatment with technology and AI

How a new grant will support the quest for a more complete map of the brain

My keynote at OHBM 2022

My interview for the OHBM blog

My interview for the OHBM Neurosalience podcast

My talk at the Oxford Autumn School in Neuroscience 2020

The IronTract Challenge featured on Computer Vision News

My talk at the LDV Vision Summit 2018

My talk at Brainhack Global 2018

My talk at the symposium on the 20 years of FreeSurfer

InStyle magazine’s Badass Women series

Fast Company’s 100 Most Creative People of 2017

Going deep: Next-generation MRI machines can look far inside the brain, and map in minute detail where things go wrong